Respected professor in UCSB’s Department of Molecular, Cellular, and Developmental Biology, David Low, will pursue a progressive global health and development research project called “Strategy for development of enteric pathogen-specific phage”. Low’s research, notes Kenny Slaught, focuses on a new way to deal with major bacterial pathogens that are becoming resistant to today’s powerful antibiotics. Low will build phage to selectively target and kill several pathogenic bacteria to eliminate enteric diseases in babies. They will engineer multiple options of the T2 lytic bacteriophage that connect multiple different regions of the BamA protein located on the surface of several pathogenic bacteria, which will mean that they only infect these specified bacteria. Furthermore, they will test the different phage for capacity to eliminate pathogenic E. coli as well as Shigella, and determine whether or not they cause resistance.
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